Posts Tagged ‘Breast Cancer’
Let’s Talk About Cancer
Cancer now dominates our community, cases are displayed in abundance in all parts of the world. Most individuals affected with this disease live with it without knowing it. For now, cancer has been considered a disease death in the world with their performance. This gradually suppress the immune system.
Research shows that cancer is “an abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize.” And we know that cancer is not just a disease actually a group. This growth was the name of a crab.
Any abnormal growth of tissue was appointed through the organ. For example, when the mother happened to have abnormal growth, then this will be diagnosed as breast cancer, as with the prostate, lung, skin, ovaries and so on.
We refer to a tumor or neoplasm or malignant, which means a disease that can grow and progress continually. Some people have no idea perplexed when it comes to benign tumors. A benign tumor is not as bad as you think, not cancer at all, and certainly the two types are not contagious.
Factors that cause inflammatory breast cancer were identified
Researchers at the University of Medicine in New York in the United States have identified factors that cause the incidence of inflammatory breast cancer, a deadly disease that is the growth of cancerous tissue derived metastases usually very quickly in the body patient .
The study was published in the journal “Nature” data giving information about this type of cancer and their origins .
On the one hand it was found that breast cancer is inflammatory consequence of excess protein identified as eIF4GI. This protein on the one hand help to make cancer cells more adhesive and is rapidly transformed into metastatic tumors.
Worth noting the extremely malignant nature of this type of cancer, at the same time represents between 1 and 2 percent of breast tumors that invade the body affected .
Arimidex in the treatment of breast cancer
As reported in the British Journal of Cancer (BJC), confirming that Arimidex (anastrozole) is an effective treatment for early breast cancer.
Arimidex is evident that offers a cost-effective alternative to tamoxifen in the adjuvant treatment of postmenopausal women with early breast cancer hormone dependent.
Arimidex continues to be the first and only aromatase inhibitor whose efficacy and safety have been extensively tested for over 5 years initial adjuvant therapy in postmenopausal women with breast cancer.
Treatment with this drug should be provided as soon as possible to reduce significantly the risk of breast cancer recurrence, while minimizing the risk of serious adverse effects.
Genes that trigger breast cancer risk
Researchers have studied the interaction of four genes identified as likely to trigger the most common tumor and feared by women, breast cancer.
The four identified genes, called FGFR2, TNRC9, MAP3K1 and LSP1 are related to the organic processes of growth and cell signaling, aspects that had not been deepened too.
The genetic pathway for the repair of DNA damage has been the most studied so far.
The idea is to decipher the genetic profile of susceptibility to breast cancer.
It is estimated that some 200 genes may be susceptibility and combinations of between 6 and 10 of these genes in a person would represent a significant risk of eventually develop a tumor.
Are beginning to identify genes and will soon be able to know what happens when a person is 2, 5 or 10 genes of these característicasta.
In the medium term, perhaps five years, this profile can be well defined and could be ready for implementation in clinical practice to identify high-risk women and early detection of tumor.
Once upon a time in San Antonio
San Antonio is a Texas city with few attractions, apart from the archaeological remains of the battle of the Alamo. However, few are dedicated to breast cancer pilgrimage there almost every year. The reason is the international symposium on breast cancer, the most important of all dedicated to the most common malignant tumor of women, the global meeting of experts where they reveal the results of more substantial research.
On 10 December, Dr. Josep Baselga (Hospital Vall d’Hebron Hospital in Barcelona and Massachusetts in the U.S.) occupied the central lectern ‘of SanAntonio’ to communicate the results of neo-ALTTO trial. This is a coordinated effort of 24 countries in Europe, America and Asia, with a huge turnout of SOLTI, a group of researchers from spain. Read the rest of this entry »
What Is Breast Cancer?
Breast cancer is an abnormal and disordered growth of cells in this tissue.
The breast is composed of a series of mammary glands that produce milk after birth, and which are called lobes and lobules.
The lobes are connected by tubes, ducts, which are those that carry milk to the nipple during lactation, to feed the baby.
The glands and the ducts are embedded in adipose tissue and connective tissue, which, together with the lymphatic tissue, form the breast.
A retaining wall as it acts pectoral muscle which lies between the ribs and breast.
Skin lines and protects the entire breast structure.
The lymphatic system consists of containers and vessels or tubes that contain and carry the lymph, a colorless liquid made up of white blood cells, mostly lymphocytes. These cells recognize any foreign substance to the body and release substances that destroy the offending agent.
Causes of breast cancer
Mutations in the genes, passed from one generation to another or acquired during life (exposure to radiation or toxic chemicals, for example, alter the genes) may also cause breast cancer. The genes BRCA1 and BRCA2, for example, are genes of susceptibility to breast and ovarian cancer. Women who carry mutations in these genes have a high risk of cancer.
The survival rate for breast cancer non-invasive is very good. For invasive cancers, the chances of recovery depend on the type of cancer and its stage of development when they began treatment. To learn more about the stages of cancer progression, see our fact sheet Cancer.
Various factors influence the speed at which a tumor will grow. Tests on a sample of tissue taken from the tumor will influence the choice of treatment.
The two tests performed:
* Test dose hormone receptors. Some types of breast cancers are sensitive to sex hormones – they are hormone. This means that their development can be stimulated by estrogen or progesterone.
* Test HER2. In cases of invasive cancer only, a genetic test is performed to ascertain the degree of activation of the HER2 gene. When this gene is strongly activated, this indicates that the cancer may grow more rapidly. This is where about 10% of invasive cancers.
Breast Cancers More Serious
About 83 percent of the original study participants, about 12,788 women were followed for five years after the trial was stopped.
After this period of 11 years, 385 women taking hormones developed invasive breast cancer, compared with 293 who took the placebo.
Women taking hormones were also more likely to have advanced cancer that had spread to lymph nodes, 81 women on hormones developed advanced cancer, while 43 women taking the placebo did.
And a total of 25 women died from breast cancer after taking hormones, compared with 12 women taking the placebo. This means that for every 10,000 women taking the therapy, 2.6 die of breast cancer per year, compared with 1.3 deaths per year among those not taking the therapy, the researchers said.
The results of the fight against the suggestion of some previous findings that breast cancers arising in women taking estrogen and progestin may be less severe and less likely to cause death than women not taking these hormones.
Type of Breast Cancer
Noninvasive cancer
* Ductal carcinoma in situ. This is the most common type of breast cancer non-invasive in women. It is a form of cancer very “young” at the very beginning of its formation. As its name suggests, is formed inside the channels of lactating breast. It does not spread. Is diagnosed much more frequently this type of cancer for more widespread use of mammography. The treatment of this cancer leads to healing in almost all cases. Without treatment, it continues to grow and can become “invasive” and thus spread outside the ducts.
Invasive cancers
* Ductal carcinoma. It starts in the ducts. Cancer cells through the wall channels.
* Lobular carcinoma. Cancer cells appear in the lobules, and then through the wall of the lobules and are scattered in the surrounding tissues.
* Inflammatory carcinoma. A rare cancer that is characterized primarily by a breast can become red, swollen and hot. The skin of the breast may also take the form of an orange peel. This type of cancer progresses faster and is more difficult to treat.
* Other carcinomas (medullary, colloid or mucinous, tubular, papillary). These types of breast cancer are more rare. The main differences between these types of cancer based on the type of cells affected.
* Paget’s Disease. A rare cancer that manifests itself through a small wound on the nipple that does not heal.
There are several risk factors for breast cancer. However, in most cases it is impossible to explain the reasons for its occurrence in a particular person.
Breast Cancer
Breast cancer is the most diagnosed cancer among women around the world.1. It occurs most often after menopause. It is not the most deadly: lung cancer remains the leading cause of cancer death among women.
One in 9 women may be suffering from breast cancer in her lifetime. Men may also be affected, but rarely. Less than 1% of cases of breast cancer affecting men.
The number of patients increased slightly but steadily over the past 3 decades. For cons, the mortality rate has steadily declined over the same period, thanks to advances in screening, diagnosis and treatment.
The breast consists of fat, glands and channels (see diagram cons). The glands arranged in lobules produce milk and canals (ducts) are used to transport the milk to the nipple. Breast tissue is influenced by hormones produced by women in varying amounts throughout their life (puberty, pregnancy, lactation). These hormones are estrogen and progesterone.
Cancer indicates the presence of abnormal cells. These abnormal cells multiply uncontrollably. Cancer cells can remain in the breast or spread throughout the body by the blood or lymphatic vessels. Most of the time, the progression of breast cancer takes many months and even years. Read the rest of this entry »