Breast Cancer
Soy to prevent breast cancer
The benefits of soy in relation to cancer and are known to science for some time, and recently made an investigation highlighted its importance in preventing colon cancer . In this case, follow the same line in cancer prevention, but this time in relation to breast cancer.
Breast cancer, one of the most common among women and one that takes more victims per year can be prevented to some degree with proper nutrition and a healthy lifestyle. Among the foods to prevent breast cancer are soybeans, which once again demonstrates its utility for health.
In research conducted by Chinese researchers who published their study in JAMA , was conducted to test women with breast cancer who were offered soy to feed, and then measured the rate of mortality and aggravation of the disease.
It was found that women who were fed soy had a 29% lower risk of mortality during the study period, plus 32% fewer cases of re-emergence of the disease.
The results are clear, and once again stop the soy goes well. Are soy isoflavones the food that make it as healthy and preventing associated with many diseases.
Breast cancer mortality reduction
The mortality rate in cancer dropped 7% during 2002-2006, from 17.9 deaths to 16.7 deaths per 100,000 persons. These data come from a study that was conducted by the Institute of Social and Preventive Medicine of the University Teaching Hospital Vaudois, in Lausanne, in collaboration with researchers from Italy.
Observation
A decrease in the number of deaths was higher among young women aged 20 to 49 years (from the European Union) or because of -11.6%. With regard to women 50 to 69 years, the reduction was more restricted to the tune of -6.6%.
Although the reduction in deaths is positive, it is important to note that breast cancer remains the main cause of deaths among women in Europe.
This decrease continued throughout the past decades is due to the advancement of therapeutic approaches available. This trend is sign of hope, because the European Union called for a reduction of 9% between 2006 and 2012. If this rate continues to drop, it is planned for late 2012, that 25 000 deaths are prevented annually.
New genetic clues are detected on breast cancer
Breast cancer is the cancer most often affects women (in fact, one in eight women in the world), and is the second leading cause of death among women worldwide. The risk of contracting it increases with age and is 2 to 4 times higher in women with a family history. The study of genetic predisposition is critical to identify gene mutations that increase the risk, either to take the necessary preventive measures, or adopt a more aggressive treatment for newly diagnosed cancer. To those already identified by scientists, just join three other genomic regions associated with breast cancer. Find it here. Saved at the core of each of our cells is the code that identifies us as a species and as individuals. Are our genes, inherited from our ancestors. We owe them our features, from height and eye color and skin to hair texture. They also owe susceptibility to certain diseases, including cancer. Thus, the study of our genetic map is a useful tool in the medical field, especially in the area of prevention. As scientists gain more information about our genes, the more effective the treatments to prevent and combat diseases that claim many lives as breast cancer, as we said, is the most common among women and reported that around 1 million new cases per year and causes about 400 000 deaths worldwide.
Although most breast cancers are of a sporadic (not related to inheritance), about 10% of cases, especially in women under 40 years, yes there is a genetic or hereditary predisposition (in these cases, the mother, daughter or sister of the patient has had breast cancer). Two thirds of these cancers are due to inherited mutations (or changes) of two specific genes called BRCA1 and BRCA2.
Fortunately, the genetic map is still revealing its secrets. Research conducted at the University of Cambridge, England recently discovered three new areas in the genome (ie, in our DNA sequence accumulated on chromosomes where genes are concentrated) that may increase the risk of developing cancer breast. Had previously identified 22 loci of susceptibility to breast cancer. A locus (means place or location, in Latin and its plural is loci). With the discovery of three new loci that number rises to 25 points of susceptibility that could explain about 9% of familial risk of breast cancer. Although the researchers admit that the impact on number of cases is relatively low, the contribution remains important in understanding the complex mechanism behind cancer and improve treatment and patient care.
For example, an area or locus has been identified is related to breast cancer estrogen receptor positive (estrogen needed for growth) and also in estrogen receptor negative. Another variant was found in a gene which plays a role in the development of mammary glands and bone. The study authors point out that it was known that the development of the mammary gland at puberty is an important step in determining the subsequent risk of cancer, but the first time it is shown that these specific genes are related to the process. These and many more details about the research are published in the January issue of the journal Nature Genetics.
The complicated and fascinating story of the genome is opening up its doors, offering new options for testing and therapy and new drugs to attack cancer more effectively.
The goal, of course, remains disposal. But until that day comes, learn and take care. Learn how to perform breast self-exams, get mammograms recommended for your age, know your risk factors and takes an active and healthy.
Factors that cause inflammatory breast cancer were identified
Researchers at the University of Medicine in New York in the United States have identified factors that cause the incidence of inflammatory breast cancer, a deadly disease that is the growth of cancerous tissue derived metastases usually very quickly in the body patient .
The study was published in the journal “Nature” data giving information about this type of cancer and their origins .
On the one hand it was found that breast cancer is inflammatory consequence of excess protein identified as eIF4GI. This protein on the one hand help to make cancer cells more adhesive and is rapidly transformed into metastatic tumors.
Worth noting the extremely malignant nature of this type of cancer, at the same time represents between 1 and 2 percent of breast tumors that invade the body affected .
Advances in the treatment of breast cancer
The technology is constantly and not just for entertainment but also for science and health. The drug treatments are increasingly comprehensive and complex, which can raise the quality of life at a rate unthinkable 25 or 30 years ago.
Patients suffering from breast cancer are those who will benefit most from the technological improvements, especially in the field of molecular microbiology. According to a recent interview to Dr. Lourdes Calvo Spanish graphic by half within a short time you can start eliminating surgery as the main option for the treatment of breast cancer .
The main idea of this research is to achieve treatment methods and cures for safer and more effective oncology. For this reason the studies are focusing on the development of individualized treatments, ie healing methods will be similar but in turn will differ from patient to patient.
In addition, Dr. Calvo said that soon a biopsy and genomic therapy will be more than enough for doctors to know what kind of cancer they are dealing, in order to prepare a specialized treatment, individual, and that allows patients to lead a normal life without having to suffer the side effects of chemotherapy or other similar practices.
Finally, we must note that in Spanish territory indicated that the level of breast cancer survival will be 90 percent in 2015.
Arimidex in the treatment of breast cancer
As reported in the British Journal of Cancer (BJC), confirming that Arimidex (anastrozole) is an effective treatment for early breast cancer.
Arimidex is evident that offers a cost-effective alternative to tamoxifen in the adjuvant treatment of postmenopausal women with early breast cancer hormone dependent.
Arimidex continues to be the first and only aromatase inhibitor whose efficacy and safety have been extensively tested for over 5 years initial adjuvant therapy in postmenopausal women with breast cancer.
Treatment with this drug should be provided as soon as possible to reduce significantly the risk of breast cancer recurrence, while minimizing the risk of serious adverse effects.
Genes that trigger breast cancer risk
Researchers have studied the interaction of four genes identified as likely to trigger the most common tumor and feared by women, breast cancer.
The four identified genes, called FGFR2, TNRC9, MAP3K1 and LSP1 are related to the organic processes of growth and cell signaling, aspects that had not been deepened too.
The genetic pathway for the repair of DNA damage has been the most studied so far.
The idea is to decipher the genetic profile of susceptibility to breast cancer.
It is estimated that some 200 genes may be susceptibility and combinations of between 6 and 10 of these genes in a person would represent a significant risk of eventually develop a tumor.
Are beginning to identify genes and will soon be able to know what happens when a person is 2, 5 or 10 genes of these característicasta.
In the medium term, perhaps five years, this profile can be well defined and could be ready for implementation in clinical practice to identify high-risk women and early detection of tumor.
Once upon a time in San Antonio
San Antonio is a Texas city with few attractions, apart from the archaeological remains of the battle of the Alamo. However, few are dedicated to breast cancer pilgrimage there almost every year. The reason is the international symposium on breast cancer, the most important of all dedicated to the most common malignant tumor of women, the global meeting of experts where they reveal the results of more substantial research.
On 10 December, Dr. Josep Baselga (Hospital Vall d’Hebron Hospital in Barcelona and Massachusetts in the U.S.) occupied the central lectern ‘of SanAntonio’ to communicate the results of neo-ALTTO trial. This is a coordinated effort of 24 countries in Europe, America and Asia, with a huge turnout of SOLTI, a group of researchers from spain. Read the rest of this entry »
What Is Breast Cancer?
Breast cancer is an abnormal and disordered growth of cells in this tissue.
The breast is composed of a series of mammary glands that produce milk after birth, and which are called lobes and lobules.
The lobes are connected by tubes, ducts, which are those that carry milk to the nipple during lactation, to feed the baby.
The glands and the ducts are embedded in adipose tissue and connective tissue, which, together with the lymphatic tissue, form the breast.
A retaining wall as it acts pectoral muscle which lies between the ribs and breast.
Skin lines and protects the entire breast structure.
The lymphatic system consists of containers and vessels or tubes that contain and carry the lymph, a colorless liquid made up of white blood cells, mostly lymphocytes. These cells recognize any foreign substance to the body and release substances that destroy the offending agent.
Causes of breast cancer
Mutations in the genes, passed from one generation to another or acquired during life (exposure to radiation or toxic chemicals, for example, alter the genes) may also cause breast cancer. The genes BRCA1 and BRCA2, for example, are genes of susceptibility to breast and ovarian cancer. Women who carry mutations in these genes have a high risk of cancer.
The survival rate for breast cancer non-invasive is very good. For invasive cancers, the chances of recovery depend on the type of cancer and its stage of development when they began treatment. To learn more about the stages of cancer progression, see our fact sheet Cancer.
Various factors influence the speed at which a tumor will grow. Tests on a sample of tissue taken from the tumor will influence the choice of treatment.
The two tests performed:
* Test dose hormone receptors. Some types of breast cancers are sensitive to sex hormones – they are hormone. This means that their development can be stimulated by estrogen or progesterone.
* Test HER2. In cases of invasive cancer only, a genetic test is performed to ascertain the degree of activation of the HER2 gene. When this gene is strongly activated, this indicates that the cancer may grow more rapidly. This is where about 10% of invasive cancers.